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Shadow Medicine: The Placebo in Conventional and Alternative Therapies

by John S. Haller

A distinguished historian of medicine, John S. Haller Jr. explores the epistemological foundations of evidence-based medicine (EBM) and the challenges it presents for both conventional and alternative therapies....


Psychopharmacology Problem Solving: Principles and Practices to Get It Right

by F. Scott Kraly

At last, a clinician’s guidebook to prescription dilemmas. Psychotropic medications prescribed to treat mental disorders have become increasingly commonplace over the past half century, but the decision-making...


Drug Metabolism Prediction

by Johannes Kirchmair, Raimund Mannhold & Hugo Kubinyi

The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists.

The authors provide more than a systematic overview of computational tools and knowledge...


The Role of the Study Director in Nonclinical Studies: Pharmaceuticals, Chemicals, Medical Devices, and Pesticides

by William J. Brock, Barbara Mounho & Lijie Fu

A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case...


Reputation and Power: Organizational Image and Pharmaceutical Regulation at the FDA

by Daniel Carpenter

The U.S. Food and Drug Administration is the most powerful regulatory agency in the world. How did the FDA become so influential? And how exactly does it wield its extraordinary power? Reputation and Power traces...


Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery

by Nicholas J. Brandon & Anthony R. West

This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these,...


Predictive ADMET: Integrated Approaches in Drug Discovery and Development

by Jianling Wang & Laszlo Urban

This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so...


Phosphodiesterases and Their Inhibitors

by Spiros Liras, Andrew S. Bell & Raimund Mannhold

Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug.

Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets...


Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse

by Linda P. Dwoskin

This new volume of Advances in Pharmacology presents the emerging targets and therapeutics in the treatment of psychostimulant abuse. With a variety of chapters and the best authors in the field, the volume...


Pharmacotherapy A Pathophysiologic Approach 9/E

by Joseph DiPiro, Robert L. Talbert & Gary Yee

25 ADDITIONAL CHAPTERS AVAILABLE ONLINE

THE LANDMARK TEXT ON HOW TO ACHIEVE OPTIMAL PATIENT OUTCOMES THROUGH EVIDENCE-BASED MEDICATION THERAPY

Pharmacotherapy: A Pathophysiologic Approach is written to help...


Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology: Principles, Delivery and Pharmacological and Biomedical Applications of Nuc

by Daniel Scherman

This unique advanced textbook provides a clear and comprehensive description of the field of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set...


Natural Products in Medicinal Chemistry

by Stephen Hanessian, Hugo Kubinyi & Gerd Folkers

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters.

Using...


Multiple Sclerosis. A Guide to Pharmacologic Treatment

by Daniel Ontaneda

The arena of multiple sclerosis (MS) treatment has changed substantially over the past 20 years. Now nine different agents are approved for use in MS with several different routes of administration, safety characteristics...


Drug Delivery Applications of Noninvasive Imaging: Validation from Biodistribution to Sites of Action

by Chun Li & Mei Tian

Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions

In vivo imaging has become an important tool for the development of new drug delivery systems,...


Scaffold Hopping in Medicinal Chemistry

by Nathan Brown, Raimund Mannhold & Hugo Kubinyi

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects.

The first section serves as an introduction...


Biological Drug Products: Development and Strategies

by Wei Wang & Manmohan Singh

Tested and proven solutions to the challenges of biological drug product development

Biological drug products play a central role in combating human diseases; however, developing new successful biological drugs...


Advanced Drug Delivery

by Ashim Mitra, Chi H. Lee & Kun Cheng

Provides both fundamentals and new and emerging applications

Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic...


Data Mining in Drug Discovery

by Ré Hoffmann, Arnaud Gohier & Pavel Pospisil

Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening...


Antibiotics: Targets, Mechanisms and Resistance

by Claudio O. Gualerzi, Letizia Brandi & Attilio Fabbretti

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics,...


Pharmacotherapy Principles and Practice Study Guide 3/E

by Michael Katz & Kathryn R. Matthias

More than 100 cases teach how you how to apply pharmacotherapeutic concepts to real-world clinical situations

Pharmacotherapy Principles and Practice Study Guide, Third Edition, includes more than 100 patient...