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Debates in History Teaching

by Ian Davies

Debates in History Teaching encourages teachers to engage with and reflect on key issues, concepts and debates in their subject. It supports you in reaching your own informed judgements, enabling you to discuss...


Phosphodiesterases and Their Inhibitors

by Spiros Liras, Andrew S. Bell & Raimund Mannhold

Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug.

Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets...


Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery

by Nicholas J. Brandon & Anthony R. West

This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these,...


Predictive ADMET: Integrated Approaches in Drug Discovery and Development

by Jianling Wang & Laszlo Urban

By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for...


Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse

by Linda P. Dwoskin

This new volume of Advances in Pharmacology presents the emerging targets and therapeutics in the treatment of psychostimulant abuse. With a variety of chapters and the best authors in the field, the volume...


Natural Products in Medicinal Chemistry

by Stephen Hanessian, Hugo Kubinyi & Gerd Folkers

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters.

Using...


Physicochemical and Biomimetic Properties in Drug Discovery: Chromatographic Techniques for Lead Optimization

by Klara Valko

Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages...


Scaffold Hopping in Medicinal Chemistry

by Nathan Brown, Raimund Mannhold & Hugo Kubinyi

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects.

The first section serves as an introduction...


Multiple Sclerosis. A Guide to Pharmacologic Treatment

by Daniel Ontaneda

The arena of multiple sclerosis (MS) treatment has changed substantially over the past 20 years. Now nine different agents are approved for use in MS with several different routes of administration, safety characteristics...


Drug Delivery Applications of Noninvasive Imaging: Validation from Biodistribution to Sites of Action

by Chun Li & Mei Tian

Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions

In vivo imaging has become an important tool for the development of new drug delivery systems,...


Data Mining in Drug Discovery

by Ré Hoffmann, Arnaud Gohier & Pavel Pospisil

Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening...


The Leukemia-Lymphoma Cell Line Factsbook

by Hans G. Drexler

This book represents an essential reference manual for all of the well-characterized leukemia-lymphoma cell lines currently available. It provides the most important facts, using the succinct and user-friendly...


Social Learning In Animals: The Roots of Culture

by Cecilia M. Heyes & Jr., Bennett G. Galef

The increasing realization among behaviorists and psychologists is that many animals learn by observation as members of social systems. Such settings contribute to the formation of culture. This book combines...


Translational Medicine - What, Why and How: An International Perspective

by B. Alving, K. Dai & S.H.H. Chan

This book is the first to provide an aerial view, as well as detailed information, on 'how' activities in translational medicine are under development in countries such as the USA, China, the UK, and Taiwan....


Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract

by L.P. Filaretova & K. Takeuchi

In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for...


Inflammation in Psychiatry

by A. Halaris & B.E. Leonard

Psychoimmunology is a rapidly maturing area of scientific endeavor that provides a compelling integrative link between the immune system and its response to stress and psychiatric illness. Stress initiates pathological...


Antibiotics: Targets, Mechanisms and Resistance

by Claudio O. Gualerzi, Letizia Brandi & Attilio Fabbretti

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics,...


Pharmacotherapy Principles and Practice Study Guide 3/E

by Michael Katz & Kathryn R. Matthias

More than 100 cases teach how you how to apply pharmacotherapeutic concepts to real-world clinical situations

Pharmacotherapy Principles and Practice Study Guide, Third Edition, includes more than 100 patient...


In Vitro Methods in Pharmaceutical Research

by Jose V. Castell & Maria Jose Gmez-Lechn

In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform...


Advanced Drug Delivery

by Ashim Mitra, Chi H. Lee & Kun Cheng

Provides both fundamentals and new and emerging applications

Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic...