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The Role of the Study Director in Nonclinical Studies: Pharmaceuticals, Chemicals, Medical Devices, and Pesticides

by William J. Brock, Barbara Mounho & Lijie Fu

A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case...


Psychopharmacology Problem Solving: Principles and Practices to Get It Right

by F. Scott Kraly

At last, a clinician’s guidebook to prescription dilemmas. Psychotropic medications prescribed to treat mental disorders have become increasingly commonplace over the past half century, but the decision-making...


Autoimmune Disease Models

by Irun R. Cohen & Ariel Miller

Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune...


Immunopharmacology of the Gastrointestinal System

by John L. Wallace & Clive Page

Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of...


Pharmaceutical Toxicology in Practice: A Guide to Non-Clinical Development

by Alberto Lodola & Jeanne Stadler

This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding...


A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery

by Terry Kenakin

A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to...


Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships

by Rathnam Chaguturu & Ferid Murad

Can academia save the pharmaceutical industry?

The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity plaguing R&D,...


Phosphodiesterases and Their Inhibitors, Volume 61

by Spiros Liras, Andrew S. Bell & Raimund Mannhold

Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug.

Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets...


Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System: From Biology to Drug Discovery

by Nicholas J. Brandon & Anthony R. West

This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these,...


Meyler's Side Effects of Drugs 15E: The International Encyclopedia of Adverse Drug Reactions and Interactions

by Jeffrey K. Aronson

Building on the success of the 14 previous editions, this remarkable reference has been extensively reorganized and expanded and now comprises almost 1,500 individual drug articles providing the most complete...


Side Effects of Drugs Annual: A worldwide yearly survey of new data in adverse drug reactions

by Jeffrey K Aronson

The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia, Meyler's Side Effects of Drugs. Each new Annual continues...


Predictive Admet: Integrated Approaches in Drug Discovery and Development

by Jianling Wang & Laszlo Urban

This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so...


Drugs of Abuse: Pharmacology and Molecular Mechanisms

by Sherrel Howard

Drug abuse has been, and continues to be, a global societal issue with diverse sets of impacts. Drugs of Abuse: Pharmacology and Molecular Mechanisms introduces the basic principles of pharmacology and neuroscience...


Biophysical Methods for Biotherapeutics: Discovery and Development Applications

by Tapan K. Das

With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.

• Helps formulation and analytical scientists in pharma...


Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse

by Linda P. Dwoskin

This new volume of Advances in Pharmacology presents the emerging targets and therapeutics in the treatment of psychostimulant abuse. With a variety of chapters and the best authors in the field, the volume...


Drug Stability for Pharmaceutical Scientists

by Thorsteinn Loftsson

Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions,...


Antipsychotic Drugs and Their Side-Effects

by Thomas R.E. Barnes & Peter Jenner

In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment...


Toxicogenomics-Based Cellular Models: Alternatives to Animal Testing for Safety Assessment

by Jos Kleinjans

Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This...


Guide to Paediatric Drug Development and Clinical Research

by K. Rose & J.N. van den Anker

Children in the developed world have never enjoyed better medical care: mortality has decreased and many fatal diseases of the past can today be prevented or even cured. However, the current practice of pharmacotherapy...


Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases

by Christophe Wiart

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and...