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GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions

by Annette Gilchrist

G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of...


Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials

by Joy A. Cavagnaro

"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology,...


Pharmaceutical and Biomedical Project Management in a Changing Global Environment

by Scott D. Babler & Sean Ekins

Pharmaceutical and Biomedical Portfolio Management in a Changing Global Environment explores some of the critical forces at work today in the complex endeavour of pharmaceutical and medical product development. ...


Chemokine Receptors as Drug Targets, Volume 46

by Martine J. Smit, Sergio A. Lira & Rob Leurs

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun...


Immunopharmacology

by David J Webb

This new volume of Advances in Pharmacology explores the current state of Alzheimer's disease research and therapeutics. Chapters cover such topics as the B cell targeted therapies, Lymphotoxin family receptors...


Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation

by Yui-Wing Francis Lam & Larisa H. Cavallari

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives....


Compatibility of Pharmaceutical Solutions and Contact Materials: Safety Assessments of Extractables and Leachables for Pharmaceutical Products

by Dennis Jenke

Compatibility of Pharmaceutical Products and Contact Materials

Dennis Jenke

Important safety aspects of compatibility for therapeutic products and their manufacturing systems, delivery devices, and containers

Compatibility...


Progress in Medicinal Chemistry

by G. Lawton & D.R. Witty

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern...


Handbook of Modern Pharmaceutical Analysis

by Satinder Ahuja & Stephen Scypinski

Handbook of Modern Pharmaceutical Analysis, Second Edition, synthesizes the complex research and recent changes in the field, while covering the techniques and technology required for today's laboratories....


Antibiotics and Bacterial Resistance

by Wiley Publications

The need for novel antibiotics is greater now than perhaps any time since the pre-antibiotic era. Indeed, the recent collapse of many pharmaceutical antibacterial groups, combined with the emergence of hypervirulent...


Drug Truths: Dispelling the Myths About Pharma R & D

by John L. LaMattina

An insider's perspective on the pharmaceutical industry

It's easy to hate Big Pharma. After all, they charge a lot of money for life-saving drugs. You could argue that Big Pharma's incentive to generate income...


Analogue-Based Drug Discovery III

by Janos Fischer, C. Robin Ganellin & David P. Rotella

Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery...


Protein-Protein Interactions in Drug Discovery

by Alexander Dömling, Raimund Mannhold & Hugo Kubinyi

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational...


PAKs, RAC/CDC42 (p21)-activated Kinases: Towards the Cure of Cancer and Other PAK-dependent Diseases

by Hiroshi Maruta

This book covers a variety of cutting-edge basic and clinical PAK research ranging from laboratory benches to hospital beds. The goal of this book is to inspire not only biomedical research scientists and university...


Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges

by Stefan R. Schmidt

The state of the art in biopharmaceutical FUSION PROTEIN DESIGN

Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents...


Ligand Efficiency Indices for Drug Discovery: Towards an Atlas-Guided Paradigm

by Celerino Abad-Zapatero

The purpose of Ligand Efficiency Indices for Drug Discovery: Towards an Atlas-Guided Paradigm is to introduce in a concise and self-contained form the concepts, ideas, applications and examples of efficiency-driven...


Elsevier's Dictionary of Vitamins and Pharmacochemistry

by Henry Philippsborn

The dictionary will contain terms covering the following fields and subfields: Vitamin Technology: Vitamin biochemistry / Physiology; Origin of vitamins: natural, synthetic; Fat-soluble vitamins; Water-soluble...


Blood-Spinal Cord and Brain Barriers in Health and Disease

by Hari Shanker Sharma

Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous...


The Practice of Medicinal Chemistry

by Camille Georges Wermuth

Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal chemistry. These chemists must acquire a good knowledge of medicinal chemistry...


Annual Reports in Medicinal Chemistry

by Anthony Wood

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected...